4-Bromo-1H-pyrrole-2-carboxylic acid ethyl ester

4-Bromo-1H-pyrrole-2-carboxylic acid ethyl ester - Names and Identifiers

Name	4-Bromo-1H-pyrrole-2-carboxylic acid ethyl ester
Synonyms	EOS-60603 RARECHEM AL BI 1264 Ethyl 4-bromopyrrole-2-carboxylate ETHYL 4-BROMO-1H-PYRROLE-2-CARBOXYLATE ethyl 4-bromo-1H-pyrrole-2-carboxylate 4-Bromo-1H-pyrrole-2-carboxylic acid ethyl ester 1H-pyrrole-2-carboxylic acid, 4-bromo-, ethyl ester 1H-Pyrrole-2-carboxylic acid, 4-broMo-, ethyl ester ENCHEM 4-BROMO-1H-PYRROLE-2-CARBOXYLIC ACID ETHYL ESTER 433267-55-1
CAS	433267-55-1
InChI	InChI=1/C7H8BrNO2/c1-2-11-7(10)6-3-5(8)4-9-6/h3-4,9H,2H2,1H3

4-Bromo-1H-pyrrole-2-carboxylic acid ethyl ester - Physico-chemical Properties

Molecular Formula	C7H8BrNO2
Molar Mass	218.05
Density	1.576±0.06 g/cm3 (20 ºC 760 Torr)
Melting Point	58-63°C
Boling Point	301.7±22.0 °C(Predicted)
Flash Point	136.3°C
Vapor Presure	0.00103mmHg at 25°C
pKa	13.58±0.50(Predicted)
Storage Condition	Inert atmosphere,Room Temperature
Refractive Index	1.56

4-Bromo-1H-pyrrole-2-carboxylic acid ethyl ester - Risk and Safety

Hazard Symbols	Xi - Irritant
Risk Codes	36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37 - Wear suitable protective clothing and gloves.
WGK Germany	3

4-Bromo-1H-pyrrole-2-carboxylic acid ethyl ester - Reference Information

application

ethyl 4-bromo-1H-pyrrole-2-carboxylate can be used as an intermediate in organic synthesis and a pharmaceutical intermediate, mainly used in laboratory research and development and chemical production.

preparation

1H-pyrrole -2-carboxylic acid ethyl ester is dissolved in acetonitrile, phosphorus oxybromide is added, the temperature is raised and refluxed for 15 hours, the reaction progress is detected by thin layer chromatography, after the reaction of the crude drug is finished, the reaction liquid is cooled to room temperature, slowly poured into the pre-cooled saturated sodium carbonate aqueous solution, the filtrate is extracted with ethyl acetate, and extracted several times, the organic layer is combined, the organic layer is dried by anhydrous sodium sulfate, and the organic phase is concentrated under reduced pressure to obtain a colorless to slightly yellow oil. After the refrigerator is placed, a solid 4-bromo-1H-pyrrole-2-carboxylate is obtained.

Last Update：2024-04-09 02:00:08